Dr Craig Gedye
(BSc(Hons) MBChB FRACP PhD )

DepartmentMedical Oncology
Research AreasHealth Promotion, Therapy and Treatment, Social Needs, Supportive Care
Research TopicsMelanoma / Skin Cancer, Brain Cancer
Research TypesClinical Trials

Cancer treatments work for many patients but fail others. This frustrating conundrum drives Dr Craig Gedye to work both at the bench and the bedside. Dr Gedye joined the Department of Medical Oncology at Calvary Mater Newcastle, and the School of Biomedical Sciences and Pharmacy at the University of Newcastle in 2014 where he is continuing his research into cancer complexity and heterogeneity at the Hunter Medical Research Institute. He is particularly interested in kidney, prostate and brain cancer, looking at how these cancers change their form and function to evade treatments.

Academic Profile

https://www.newcastle.edu.au/profile/craig-gedye

Publications / achievements

Clinical Research Activity

1. Chair, Renal Cancer Subcommittee, ANZUP Cancer Trials Group

2. Scientific Advisory Committee, ANZUP

3. Scientific Advisory Committee, Mark Hughes Foundation

4. Site PI on five active trials with multiple trials pending.

5. Investigator-initiated clinical trial protocols

a. Three in active development

b. Three in proposal phase.

Prizes, Awards, Fellowships, Scholarships and Distinctions

1. 2014 ANZUP ASM Best of the Best Poster Prize (AUD$1000).

2. 2014 American Society of Clinical Oncology Merit Award (USD$1000).

3. 2013 Canadian Cancer Society Travel Award (CAD$1762).

4. 2013 Novartis Oncology Young Canadian Investigator Award (CAD$5000)

5. 2012 Canadian Institute of Health Research (CIHR)/Kidney Cancer Canada (KCC) Small Health Organization Partnership Program (SHOPP) Postdoctoral Fellowship (total funding of CAD$92,000 over 20 months).

6. 2010 National Health and Medical Research Council Training (Postdoctoral) Fellowship (total funding of AUD$341,000 over four years 2010 – 2012; 2014 – 2016).

7. 2010 Royal Australasian College of Physicians CSL Fellowship (AUD$20,000).

8. 2008 Ludwig Institute for Cancer Research Student Commendation.

9. 2008 Royal Australasian College of Physicians CSL Fellowship (offered).

10. 2008 COSA/MOGA/HSANZ Roche HOTT Fellowship (AUD$50,000).

11. 2007 MOGA ASM Best Consultant Speaker Prize.

12. 2007 Royal Australasian College of Physicians Australia Post Research Fellowship (AUD$30,000).

13. 2004 NHMRC Biomedical Research PhD Scholarship (AUD$94,500 over 3½ years).

14. 2004 Medical Oncology Group of Australia/Pfizer Australia Trainee Travel Award.

Core Funding

15. 2015 Mark Hughes Foundation Project Grants: “Bringing CLARITY to brain cancer” and “BAALC – a novel target for the development of new treatments for brain cancer”, total of $29,000.

16. 2015 HCRA Pilot Grant Funding; three projects, total of $33,000.

17. 2014 Kidney Health Australia 2014 Medical Research Grant, $46,000; Destroying Kidney Cells that Evade Current Treatments Regulation and Therapeutic Targeting of Mesenchymal Differentiation and De-Differentiation in Clear Cell Renal Cell "Carcinoma” CI Craig Gedye, AIs Rodney Scott, Nikola Bowden.

18. HMRI/Mark Hughes Foundation Grant, “The Virtuous Circle: A Living Brain Cancer BioBank”, CIs Rodney Scott, Craig Gedye, total funding $74,650.

19. 2014 CINSW Equipment Grant: Aperio II. Stephen Ackland, Rodney Scott, John Forbes, Xu Dong Zhang, Stephen Braye, Marjorie Walker, Hubert Hondermarck, Craig Gedye, Rick Thorne, Loui Rassam, total funding $470 000.

20. 2014 CINSW Equipment Grant: Micromanipulator: Investigators Paul de Souza, Therese Becker, Minoti Apte, Kevin Spring, Marie Ranson, Graham Mann, Craig Gedye, Mark Cowley, total funding $270,000.

21. 2014 CINSW BSN Biobanking Consent Project Grant (2014-5). Investigators Rodney Scott, Christine Paul, Craig Gedye, Nicholas Hawkins, Phil Crowe, Deborah Marsh, total funding $275,000.

Getting to know you

When did you start doing research?

1990. I had a summer research project and found an old drug that inhibited an important enzyme in white blood cells.

What research projects are you currently working on?

Translational research projects to better understand the complexity and differences between different patients’ cancers. Basic science research projects studying heterogeneity and treatment resistance in renal cell carcinoma (kidney cancer). Clinical research with trials in kidney cancer, bladder cancer and brain cancer.

What research achievement are you most proud of?

I managed to establish a multi-department collaboration that created a whole new field of research, winning new funding, new positions and most importantly some really important findings that change the way we see cancers in general, and kidney cancer in particular.

What inspires you?

People. Patients carrying cancers, their families carrying their hopes, fears and expectations, health-carers trying to give the best care in the face of imperfect knowledge and limited resources, and scientists trying to find new treatments and better ways of delivering existing therapies.

What did you do before coming to work at Calvary Mater Newcastle?

A clinical and postdoctoral Fellowship at the Princess Margaret Hospital, Toronto, Canada. It was cold. Very cold. But Canadians are amazing and it’s a marvellous centre to work in.

What has helped you the most in your research at Calvary Mater Newcastle?

Again, people. There is a core of committed people at Calvary Mater Newcastle, HMRI and the University of Newcastle, that are making cancer research a really exciting complement to my clinical work.

Who are your main collaborators at Calvary Mater Newcastle?

The clinical trials team at Medical Oncology Research, but I am working with clinicians and scientists across multiple campuses in Newcastle.

What did you do before you became a researcher?

Clinical training as a cancer specialist.

What made you decide to do research?

Initially the excitement of seeking new knowledge. But what keeps me going is the challenge of trying to give the “best” treatment I can to every patient, but knowing that we need to find better treatments, and to use existing treatments more effectively.

What was your first / worst / best / strangest / memorable job in research?

The worst and strangely the best thing that happened to me was finding out that the resources I had been using to do my PhD were corrupted. I had to repeat two years of my work. It only took me one year to repeat, and it taught me the most important lesson of being a scientist – trust but verify.

What is the craziest thing you have ever had to do “in the name of research”?

Using a Wil. E. Coyote-esque room-filling blown-glass contraption to try and extract the chemicals that make small fish smell differently. The fish came from all over the world! Yes, I did end up smashing the glass (but it was easily fixed). No, we didn’t get any fishy results. And I cleaned up afterwards; nothing was out of plaice!

What do you do to relax?

Time with family, running and reading.

 

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