Dr Janine Lombard
(MbChB MMed (Int) Cert Med Onc (SA) FRACP)

DepartmentMedical Oncology
Research AreasDiagnostics / Screening, Therapy and Treatment
Research TopicsBreast Cancer, Gynae-oncology
Research TypesClinical Trials, Laboratory Research

Dr Janine Lombard has been conducting breast and gynaecological research in the Medical Oncology Research Department at Calvary Mater Newcastle since 2006. Her main interest is breast and gynaecological cancers and measures to improve both outcomes but also reduce the toxicities of treatments for these diseases. Dr Lombard is involved in basic translation research through links with researchers at HMRI and the University of Newcastle in breast and ovarian cancer. She has also been involved in several important trials in early and advanced breast cancer treatments, some of which have significantly changed clinical practice. Her involvement in the POEMS study helped to establish the use of a drug to protect fertility and prevent early menopause symptoms in women with estrogen negative early breast cancer.

Publications / achievements

Principal investigator for Australian and New Zealand for two international breast cancer trials, representing the Australia New Zealand Breast Cancer Trials Group.

Age related increase in mTOR activity contributes to the pathological changes in ovarian surface epithelium. Bajwa P, Nagendra PB, Nielsen S, Sahoo SS, Bielanowicz A, Lombard JM, Wilkinson JE, Miller RA, Tanwar PS.

Aromatase inhibitor induced musculoskeletal syndrome: a significant problem with limited treatment options. Lombard JM, Zdenkowski N, Wells K, Beckmore C, Reaby L, Forbes JF, Chirgwin J. Support Care Cancer. 2016 May;24(5):2139-46. doi: 10.1007/s00520-015-3001-5. Epub 2015 Nov 10.

Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy. Moore HC, Unger JM, Phillips KA, Boyle F, Hitre E, Porter D, Francis PA, Goldstein LJ, Gomez HL, Vallejos CS, Partridge AH, Dakhil SR, Garcia AA, Gralow J, Lombard JM, Forbes JF, Martino S, Barlow WE, Fabian CJ, Minasian L, Meyskens FL Jr, Gelber RD, Hortobagyi GN, Albain KS; POEMS/S0230 Investigators. N Engl J Med. 2015 Mar 5;372(10):923-32.

Epithelioid trophoblastic tumour simulating a high grade carcinoma. Pluschke A, Jaaback K, Scott RJ, Lombard J, Yin H. Pathology. 2014 Apr;46(3):248-50. doi: 10.1097/PAT.0000000000000088.

Cediranib in combination with fulvestrant in hormone-sensitive metastatic breast cancer: a randomized Phase II study. Hyams DM, Chan A, de Oliveira C, Snyder R, Vinholes J, Audeh MW, Alencar VM, Lombard J, Mookerjee B, Xu J, Brown K, Klein P. Invest New Drugs. 2013 Oct;31(5):1345-54. doi: 10.1007/s10637-013-9991-2. Epub 2013 Jun 26.

Early detection of treatment induced cardiac toxicity - can we do better? Lombard JM, Paterson R. Asia Pac J Clin Oncol. 2013 Jun;9(2):97-8. doi: 10.1111/ajco.12085.

Changes in medical oncology admissions for the management of breast cancer complications: an Australian institution's experience. Day FL, Bull JM, Lombard JM, Stewart JF. Asia Pac J Clin Oncol. 2011 Jun;7(2):146-53. doi: 10.1111/j.1743-7563.2011.01391.x. PMID: 21585694

Getting to know you

When did you start doing research?

2006.

What research projects are you currently working on?

Investigator for several breast and gynaecological cancer studies being run at Calvary Mater Newcastle. Principal investigator representing Australian sites for two international breast cancer trials, one in neoadjuvant breast cancer treatment and one in metastatic breast cancer. Affiliation with basic science research in breast cancer and ovarian cancer.

What research achievement are you most proud of?

Principal investigator representing Australian sites for two international breast cancer trials. One of these trials has established a new drug, palbociclib, as a treatment for relapsed breast cancer. My role as an investigator in the POEMS study which established the role of ovarian suppression as a way of reducing menopausal symptoms and improving fertility of breast cancer patients receiving chemotherapy is also a highlight.

What inspires you?

My patients and their grace and courage in their disease journey inspires me daily. 

What did you do before coming to work at Calvary Mater Newcastle?

I lived in South Africa and worked in a large academic hospital there.

What has helped you the most in your research at Calvary Mater Newcastle?

My relationships with other researchers and the amazing research staff that are so busy but constantly striving to provide quality data.

Who are your main collaborators at Calvary Mater Newcastle?

Other researchers in Medical Oncology. 

What did you do before you became a researcher?

Finished oncology training. 

What made you decide to do research?

I wanted to do more than just clinical work, and I hoped that through research I could help to improve the outcomes for patients.  

What do you do to relax?

Garden, run and spend time with my family.

 

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