Dr Jayne Gilbert
(PhD, Hospital Scientist, Medical Oncology )

DepartmentMedical Oncology
Research AreasTherapy and Treatment
Research TopicsBreast Cancer, Prostate Cancer, Melanoma / Skin Cancer, Head and Neck Cancer
Research TypesLaboratory Research

Dr Jayne Gilbert has been conducting lab based research for the Medical Oncology Department since 2004. Her research interests combine a knowledge of molecular and cellular biology, with a strong focus on drug development for the treatment of cancer. As part of the experimental therapeutics group under the direction of Dr Jennette Sakoff, the aim is to identify better therapy agents that can be used as single agents or in combination with conventional chemotherapeutic drugs to improve the treatment and overall survival for patients diagnosed with cancer.

Publications

Since 2009

  • Sauer B, Gilbert J, Sakoff JA, McCluskey A (2009) Synthesis of 4-substituted-3-hydroxy-5-oxo-10-oxa-4-azatricyclo[5.2.1]dec-3-yl acetic acid ethyl esters as norcantharidin analogues. Letters in Drug Design and Discovery, 6(1): 1-7 (IF 0.562).
  • Ian P. Holland, Adam McCluskey, Jennette A. Sakoff, Jayne Gilbert, Ngoc Chau, Phillip J. Robinson, Cherie A. Motti, Anthony D. Wright, and Ian A. van Altena (2009). Steroids from an Australian Sponge Psammoclema sp. Journal of Natural Products 72(1): 102-106. (IF 3.159, ERA C.
  • Thaqi A, Scott JL, Gilbert J, Sakoff JA, McCluskey A. (2010) Synthesis and biological activity of Delta-5,6-norcantharimides: importance of the 5,6-bridge. Eur J Med Chem 45(5): 1717-23. (IF 3.3).
  • Joshi S, Perera S, Gilbert J, Smith CM, Mariana A, Gordon CP, Sakoff JA, McCluskey A, Robinson PJ, Braithwaite AW, Chircop M. (2010) The Dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells. Mol Cancer Ther. 9(7) 1995-2006 (IF 5.225).
  • Tarleton M, Gilbert J, Robertson MJ, McCluskey A, Sakoff JA. (2011) Library synthesis and cytotoxicity of a family of 2-phenylacrylonitriles and discovery of an estrogen dependent breast cancer lead compound. Med Chem Comm. 2, 31-37.
  • Robertson MJ, Gordon CP, Gilbert J, McCluskey A, and Sakoff JA. (2011) Norcantharimide analogues possessing terminal phosphate esters and their anti-cancer activity. Bioorg. Med. Chem. 19, 5734-41 (IF 2.978).
  • Campbell BE, Tarleton M, Gordon CP, Sakoff JA, Gilbert J, McCluskey A, Gasser RB. (2011) Norcatharidin analogues with Nematocidal activity in Haemonchus contortus. Bioorganic & Medicinal Chemistry Letters. 21, 3277-81 (IF 2.661).
  • Chircop M, Perera S, Mariana A, Lau H, Ma MPC, Gilbert J, Jones NC, Gordon CP, Young KA, Morofoff A, Sakoff JA, O'Brien TJ, McCluskey A and Robinson PJ. (2011) Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells.  Molecular Cancer Therapeutics. 10, 1553-1562 (IF 5.225).
  • Tarleton M., Gilbert J., Sakoff JA., and McCluskey A. (2012) Synthesis and anticancer activity of a series of norcantharidin analogues. European Journal of Medicinal Chemistry. In press (IF 3.3).
  • Tarleton M, Gilbert J, Sakoff JAand McCluskey A. Cytotoxic 2-phenyacrylnitriles, the importance of the cyanide moiety and discovery of potent broad spectrum cytotoxic agents. (2012) Eur. J. Med. Chem. 57, 65-73 IF = 3.35.
  • Tarleton M, Dyson L, Gilbert J,  Sakoff JA and McCluskey A. Focused library development of  2-phenylacrylamides as broad spectrum cytotoxic agents. (2013) Bioorgan. Med. Chem.  21, 333-47. IF = 3.1.
  • Deane FM, MaguireAR, Gilbert J, Sakoff JA, McCluskey A, and McCarthy FO.  (2013) Synthesis and evaluation of novel ellipticines as potential anti-cancer agents. J. Med. Chem. 11, 1334-44. IF = 5.2

 

Getting to know you

When did you start doing research?

My first research assistant job was in 1989 when I was doing my BSc at the University of Technology in Sydney. The position was at the Children's Cancer Research institute in Sydney where I then went on to do my honours and PhD.

What research projects are you currently working on?

I am currently working on multiple projects that involve screening and developing new drugs for the treatment of cancer. 

What research achievement are you most proud of?

I was able to develop a faster technique for identifying the copy number of a gene important in the childhood cancer neuroblastoma.

What inspires you?

My niece.

What did you do before coming to work at Calvary Mater Newcastle?

Before coming to work at Calvary Mater I did a two-year postdoctoral position at the Albert Einstein College of Medicine in the Bronx, New York.

What has helped you the most in your research at Calvary Mater Newcastle?

The staff of the Medical Oncology Department, especially the tea room, where all the world's problems are solved.

Who are your main collaborators at Calvary Mater Newcastle?

Dr Jennette Sakoff, Dr Steve Ackland, Madhu Garg.

What did you do before you became a researcher?

I was at school and would babysit for money.

What made you decide to do research?

Have no idea what made me decide to do research but at the age of 16 I knew that was what I wanted to do.

What do you do to relax?

I love to read and hang out with my fiance and my spoiled cat.

 

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