Ms Madhu Garg
(MSc, Hospital Scientist, Medical Oncology
|Research Areas||Diagnostics / Screening, Genetics, Therapy and Treatment|
|Research Topics||Breast Cancer, Prostate Cancer, Head and Neck Cancer, Blood and bone marrow disorders, Side Effects / Adverse Reactions / Poisoning|
|Research Types||Clinical Trials, Laboratory Research|
Ms Madhu Garg has been conducting lab based research for the Medical Oncology Department since 1993. As part of the experimental therapeutics group, She has been involved in various cancer research projects including drug pharmacokinetics / pharmacodynamics, pharmacogenetics, drug combination studies, screening new drugs, telomere biology and drug stability studies. She has developed high performance liquid chromatography (HPLC) and LC-MS methods to assess a number of anticancer agents in cancer patient samples and has gained reputation to a level that Calvary Mater Newcastle Medical Oncology Laboratory now receives samples from all over Australia / New Zealand as they are the only facility in Australia with the expertise to conduct these studies.
- Wong, M., Balleine, R.L., Blair, E.Y.L., McLachlan, A., Ackland,S.P, Garg, M.B., Evans,S. Farlow,D., Collins,M., Rivory, L.P., Hoskins,J.M., Mann,G.J., Clarke, C.L., Gurney, H. (2006) Predictors of vinorelbine pharmacokinetics and pharmacodynamics in patients with cancer . J Clin Oncol. 24:2448-2455 (IF 17.793, ERA A*).
- Lincz, L.F., Scorgie, F.E., Garg, M.B., Ackland, S.P. (2007) Identification of a single nucleotide polymorphism in the first tandem repeat sequence of the thymidylate synthase 2R allele. International J cancer, 120 (9) 1930-1934 (IF 4.722, ERA A).
- Lincz, L.F., Scorgie, F.E., Garg, M.B., Ackland, S.P. (2007) Classification of thymidylate synthase gene enhancer region polymorphisms. International J cancer, letter to the Editor, response to IJC-07-1147.
- deBock E C., Garg, M.B., Scott, N., Sakoff, J.A., Scorgie,F.E, Ackland,S.P, Lincz,L.F. (2011) Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo. The Pharmacogenomics Journal , 11 (4), 307?314; (IF 5.435, ERA A).
- Garg, M.B, Ackland, S.P. (2011) Pyridoxine to protect from oxaliplatin-induced neurotoxicity without compromising antitumour effect.Cancer Chemother Pharmacol 67(4):963-966 (2011) (IF 2.759, ERA B).
- Garg M.B., Sakoff J.A., Ackland S.P. (2011) A simple HPLC method for plasma level monitoring of mitotane and its two main metabolites in adrenocortical cancer patients. J Chromotography B. 879: 2201-2205 IF = 2.971, ERA = B.
- Agrez, M.V., Garg, M.B., Dorahy, D.J., Ackland,S.P. (2011) Synergistic anti-tumor effect of cisplatin when combined with an anti-Src kinase integrin-based peptide. J Cancer Therapy, 2: 295-301.
- Garg M.B, Lincz, L.F., Adler, K., Scorgie, F.E , Ackland, S.P., Sakoff, J.A.(2012) Predicting 5-Fluorouracil Toxicity in Colorectal Cancer Patients from peripheral blood cell telomere length ? A multivariate Analysis. British J Cancer: 107,1525-1533 IF=5.042 , ERA=A.
- Agrez, M.V., Garg, M.B., Ackland,S.P. (2012) Novel anti-cancer peptides comprising three amino acids. Journal of Cancer Therapy, Vol 3: 230-236.
Getting to know you
When did you start doing research?
My first research job was at University of Alberta, Edmonton, Alberta, Canada in year 1990 working as a Biochemistry technician working in neonatal Research laboratory.
What research projects are you currently working on?
I am currently working on multiple cancer research projects including drug pharmacokinetics/pharmacodynamics, pharmacogenetics, drug combination studies, telomere biology and screening new drugs for the treatment of cancer.
What research achievement are you most proud of?
I have developed high performance liquid chromatography (HPLC) and LC-MS methods to assess a number of anticancer agents in cancer patient samples and has gained reputation to a level that Calvary Mater Newcastle Medical Oncology Laboratory now receives samples from all over Australia / New Zealand as we are the only facility in Australia with the expertise to conduct these studies.
What inspires you?
To see that my work is making difference in some cancer patients lives.
What did you do before coming to work at Calvary Mater Newcastle?
I worked at University of Alberta, Edmonton, Alberta, Canada as a Biochemistry technician in Neonatal Research Laboratory and Department of Animal Science.
What has helped you the most in your research at Calvary Mater Newcastle?
The helping nature of all the staff in Medical Oncology Department, especially of my supervisor Professor Stephen Ackland has been very encouraging for me to work at the Mater.
Who are your main collaborators at Calvary Mater Newcastle?
Professor Stephen Ackland, Dr Jennette Sakoff, Dr Jayne Gilbert, Dr Lisa Lincz, Fiona Scorgie, Kim Adler and Cathy Johnson.
What did you do before you became a researcher?
I was studying at College / University.
What made you decide to do research?
I was always interested in science/mathematics and that prompted me to do research as my career.
What do you do to relax?
I watch TV to relax and like to spend time with my family and friends